I feel like a lot of the suggestions in this thread would lead to unnecessary micromanagement or high levels of complexity and are probably better left to the modding community. I'd like to see the game embrace new urbanism. The critical missing piece is the lack of mixed use zoning. Both offices and high density residential should offer the option of ground-floor commercial. These would not completely satiate the demand for commercial zoning but it would meet some of the demand. Secondary to that it would be good to see walkable neighborhoods behave as they do in real life, with higher property values, people not owning cars, etc. I also have some minor quibbles with things like noise pollution. Does a water tower really cause noise pollution in real life? That doesn't seem realistic.