The game is a solid year, year and half and probably more realistically two-years away (has a game ever made it out on it's first announced date(s)?) I think it's a wee bit early to say, for sure, what this game will and will not have in it and what will and will not be required in order to play it. Backlash against the Origin/"always online" bit could force EA to change their minds or go a different route. I'd say we wait until we get a lot more info before writing the game off.
Always being logged into/connected to a server doesn't greatly sit well for me but if the simulation and gameplay are great and match or rival the current state of SC4:Rush Hour (with mods) I'll be there. Heck, I'd be happy if it was that with just updated graphics and a 3D camera.
It's been a long 9-10 years since we've had a decent SImCity game (I'm looking at you, Societies) and I'll certainly give this one a try. Plus it means I get an excuse to build a brand new computer with the latest specs next year, too!