velShandru

With multiple choices yet . On the freeware side PlayOnMac, a port of PlayOnLinux is my personal preference since it stores its working files in Mac folders for ease of access. VirtualBox uses virtual machines so you'll need a WinDoze license, but is quite competitive with the pay-for options: Parallels and VMware Fusion (sadly for us, the freebie VMware Workstation Player is only available for Linux and Windoze). I have used all 4 options over the years but very much prefer Fusion in the paid space and the Wine based PlayOnMac for running just one or two apps (I run High Sierra on a 2011 Mac mini). All four now permit cut & paste interoperability with MacOS, so which of those you'd want to use depends on how you plan to use it and your personal interface preferences.

catty-cb gave you where to look for the game files, but note that our user files are stored at ~/Documents/SimCity 4 — this is where we need to install any plugins or regions we wish to use. I generally drop an alias to that folder in my Games folder. SC4 folder icon attached FYI. SC4.icns