This is absolutely insane, the fix actually worked. I've spent the last 2 days trying a billion different things (yes, including following the SC4 ultimate guide essential fixes to a T) and limiting CPU count to 1 in steam launcher settings, yet setting prefer max performance in nvidia control panel is what actually got the game stable.
RTX 3080 5800x3d 32gb ram, windows 10 pro for reference.
It really seems Nvidia messed something up recently.
Ulisse I suggest putting a little sticky or something somewhere in the critical mod list section to this thread or that fix, seems to be a common issue at least for RTX 3000 GPUs.