Edit: Not crashing as often now, maybe 1 in 4 times. Am able to go through Origin. I had a Infinite restart loop issue when SimCity tried to update, but that seems to be unrelated to wine and was fixed with instructions from http://answers.ea.com/t5/Updater/Infinity-loop-restarting-Simcity/m-p/889080#M2745
Old Post -
Currently I have 1 major problem, and that is that it is unstable. i.e I need to start it with SimCity.exe directly, and even then, 4 times out of 5 it crashes before loading the city. Once it loads the City it is typically fine after that. This is mentioned in the AppDB page as well