Most things i can think of have already been listed in posts before me so i wont bother repeating, but something i would find interesting is varying game speeds in terms of construction.
To enjoy a really good simulation when building my city i would like it if there was longer construction times for buildings and road networks. Building a long motorway should become a large task and a big investment which requires lots of money and time to build rather then a few seconds.
Obviously it would get annoying if it took literally hours for a new motorway to be finished but some kind of option to adjust speed of construction in the game settings would be appreciated to make things a bit more interesting.