Those sims, bad, bad.
They are quite demanding. Pun, do you see it? Never mind that. I have a large space in the district of New Saint Ralph called Zeus. I consider my region one big city and my cities and districts in my one big city.
Zeus District is very promising. In just one corner connected to a huge amount of other district already has 400,000 sims. Problem is, sim complain of unemployment, despite all the jobs available. I have a lot of transit types, monorail, avenues, highways, rail and elevated rail and subway systems. So, I'm combatting commute times. What I hate is that these potential employers abandon their buildings that took forever to grow and this saddens me.
I suppose I'll just work on surrounding districts to create me demand and rebuild the skyscrapers.