I have the same situation: during installation, everything ran fine, and when prompted to install updates I went ahead and did so - apparently this was required to keep the game functioning lol. Post-update, the game immediately crashes... I don't get any further than a crash message - no login screen, no splash screen, nothing.
Vista 32 bit
Intel Core 2 Quad Q6600 2.4GHz
4GB RAM
nVidia 9800 GTX 512MB
My rig's a year old but I still decimate everything I throw at it, and even doing development there's no issues. The patch obviously broke something, but I figured I'd add myself to the list of the effected.