My experiment proved myself wrong. I was able to exceed 200,000 Sims in a medium sized city with the CAM and no custom large buildings. My Sims were partially employed in the city but were mostly employed by Industria to the South and Marcopolis to the East. In order to build it up, I needed to build subway lines from Marcopolis to Mezaton, build more train stations, build a large high school and a library in the newest residential district (formerly commercial and an airport, I moved the airport to Marcopolis next door), build a few parks, and cover the city with as much God Mode trees as possible.
Total cheats: CAM demand, weaknesspays 16 times over region, segregation exploit
Mezaton Alpha day:
Mezaton Alpha night:
Total Residential population: 207,120